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aldX [2019-08-13 09:52:34]
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aldX [2019-08-13 09:52:34]

aldehyde dehydrogenase (NAD)
locus
BSU_39860
pI
4.84
mw
49.41 kDa
protein length
445 aa Sequence Blast
gene length
1338 bp Sequence Blast
function
unknown
product
aldehyde dehydrogenase (NAD)
essential
no
ec
1.2.1.3
synonyms
yxaS,yxbE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

    • Gene

    Coordinates
    4,093,980 → 4,095,317

    The protein

    Catalyzed reaction/ biological activity

  • An aldehyde + NAD+ + H2O = an acid + NADH (according to Swiss-Prot)

    • Protein family

  • [SW|aldehyde dehydrogenase family] (according to UniProt)

    • Paralogous protein(s)

  • [protein|F9CF067A2A8E3B2BACC6A51A0E87E84640349980|AldY], [protein|1ADC55F8E265AF86E29743C671CE1EA1BE7EB41E|GbsA], [protein|2042F691CB37B1BAFE2CF3906A9F7F47457C3995|PutC], [protein|5B66ADB81AB141982F187B1C5E3A9346AA064DE2|YcbD], [protein|67A72A0EABCD807C25D8EAC61C251142B45C174E|DhaS], [protein|69838717DC6BB27864D88C282BF5BC7CC558BFD7|RocA], [protein|762718A15E5256261D79DF60F9106AF0CE2D60C6|IolA], [protein|99F1FAF28FB4817D94E84BD5288FA33124558933|YwdH], [protein|A0BEB92D54799956A4ADE106A1388E5710141069|GabD], [protein|EF0AAAF5BAE8E1F54FCA296643F7B9E3CE257B1D|YfmT]

    • Structure

  • [PDB|3RHH] (from ''Bacillus halodurans'' C-125 complexed with NADP, 29% identity, 61% similarity)
  • [PDB|4QGK] (from ''Homo sapiens''(42%))

    • Expression and Regulation

    Operons

    genes
    [gene|F3341F205CB939498109D2A54DE842065C488DD5|aldX]
    description
    [Pubmed|10746760]
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    Biological materials

    Mutant

  • MGNA-B692 (aldX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1691 NBRP B. subtilis, Japan]
  • BKE39860 (Δ[gene|F3341F205CB939498109D2A54DE842065C488DD5|aldX]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE39860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTAAAATCCCCCTCAT, downstream forward: _UP4_TAATCGCATGATCAAAAGGC
  • BKK39860 (Δ[gene|F3341F205CB939498109D2A54DE842065C488DD5|aldX]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK39860 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTAAAATCCCCCTCAT, downstream forward: _UP4_TAATCGCATGATCAAAAGGC

    • References

  • 10746760